LAUDA provides temperature control at -80 °C for freeze-dryer
Lauda-Königshofen, September 9 2020 – LAUDA, the world market leader for temperature control equipment and systems, has been manufacturing customer-specific refrigeration systems for pharmaceutical companies for more than 50 years. The company has now completed a cryogenic cooling system for use in a pharmaceutical freeze-drying plant. This enables pharmaceutical substances to be gently frozen at -80 °C. The order was placed by Martin Christ Gefriertrocknungsanlagen GmbH, one of the world’s leading freeze-dryer companies with more than 70 years of experience in this field. Martin Christ relies on the expertise of LAUDA for the reliable provision of the deep-freeze environment. A Kryopac Secondary Circuit Unit from LAUDA Heating and Cooling Systems, the plant construction division of the temperature control specialist, which plans and manufactures exactly according to customer requirements, provides the requisite cooling capacity.
Liquid nitrogen provides temperatures down to -115 °C
Freeze-drying makes use of a physical phenomenon
Freeze-drying is an extremely gentle preservation method, as the chemical properties of the source substances are not changed. All the active ingredients in pharmaceutical products are therefore preserved. This type of preservation is also used for sample preparation in laboratories, in the food industry or archeology, for example to preserve wet leather or wood.
The refrigeration system of the Kryopac system cools the shelves on which vessels filled with drugs are placed with a cooling capacity of 30 kW at – 80 °C and freezes the pharmaceuticals in two and a half hours. Heat is supplied during evacuation, the removal of air by creating a vacuum. This results in a physical phenomenon called sublimation: The frozen water evaporates without liquefying. The drug is dried directly from the frozen state. The resulting water vapor is deposited on the ice condenser of the freeze-dryer in the form of ice crystals. The ice condenser is maintained at a temperature of -80 °C by the Kryopac system. A complete freeze-drying process typically takes 48 hours.
The Kryopac system was initially completely tested at LAUDA and then subjected to a further thorough inspection as a complete system at Martin Christ before the freeze-dryer was delivered to the end customer. However, this is not the end of the cooperation. As a result of the successful working relationship and implementation of this project, Martin Christ has already ordered two more LAUDA Kryopac Secondary Circuit Units.